Clinical Importance of Myc Family Oncogene Aberrations in Epithelial Ovarian Cancer
Abstract
The Myc oncogene family has been implicated in many human malignancies and is often associated with particularly aggressive disease, suggesting Myc as an attractive prognostic marker and therapeutic target. However, for epithelial ovarian cancer (EOC), there is little consensus on the incidence and clinical relevance of Myc aberrations. Here we comprehensively investigated alterations in gene copy number, expression, and activity for Myc and evaluated their clinical significance in EOC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2018
- Source ID
- 10.1093/jncics/pky047
Entities
People
- Amanda J. Russell
- Andrew J. Gifford
- Anna deFazio
- Catherine Kennedy
- David D. Bowtell
- Kylie-ann Mallitt
- Michelle Haber
- Michelle J Henderson
- MoonSun Jung
- Murray D. Norris
- Siva Sivarajasingam
- The Australian Ovarian Cancer Study Group
Organizations
- Cancer Institute of New South Wales
- Garvan Institute of Medical Research
- National Health and Medical Research Council
- Prince of Wales Hospital, Sydney
- UNSW Lowy Cancer Research Centre
- United States Army Medical Research and Development Command
- University of New South Wales
- University of Sydney