PTHrP, A Biomarker for CNS Metastasis in Triple-Negative Breast Cancer and Selection for Adjuvant Chemotherapy in Node-Negative Disease
Abstract
Triple-negative breast cancer (TNBC) is characterized by poor prognosis and lack of targeted therapies and biomarkers to guide decisions on adjuvant chemotherapy. Parathyroid hormone-related protein (PTHrP) is frequently overexpressed in breast cancer and involved in proliferation and metastasis, two hallmarks of poor prognosis for node-negative breast cancer. We investigated the prognostic value of PTHrP with respect to organ-specific metastasis and nodal status in TNBC.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 29, 2019
- Source ID
- 10.1093/jncics/pkz063
Entities
People
- Abu Shadat Mohammod Noman
- Agnihotram V Ramana Kumar
- Anne Camirand
- Atilla Omeroglu
- Bassam Abdulkarim
- Gloria Assaker
- Jean Deschenes
- Kurian Joseph
- Richard Kremer
- Siham Sabri
Organizations
- McGill University
- McGill University Health Centre
- Montreal General Hospital
- United States Department of Defense
- University of Alberta
- University of Chittagong