Molecular Correlates of Socioeconomic Status and Clinical Outcomes Following Hematopoietic Cell Transplantation for Leukemia
Abstract
Clinical outcomes among allogeneic hematopoietic cell transplant (HCT) recipients are negatively affected by low socioeconomic status (SES), yet the biological mechanisms accounting for this health disparity remain to be elucidated. Among unrelated donor HCT recipients with acute myelogenous leukemia, one recent pilot study linked low SES to increased expression of a stress-related gene expression profile known as the conserved transcriptional response to adversity (CTRA) in peripheral blood mononuclear cells, which involves up-regulation of pro-inflammatory genes and down-regulation of genes involved in type I interferon response and antibody synthesis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 12, 2019
- Source ID
- 10.1093/jncics/pkz073
Entities
People
- Brent R. Logan
- J. Douglas Rizzo
- Jennifer M. Knight
- Jesusa M G Arevalo
- Michael R Verneris
- Naya He
- Stephanie J. Lee
- Stephen R. Spellman
- Steve W Cole
- Tao Wang
Organizations
- American Cancer Society
- Health Resources and Services Administration
- Medical College of Wisconsin
- National Cancer Institute
- National Center for Advancing Translational Sciences
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Marrow Donor Program
- Office of Naval Research
- United States Public Health Service
- University of California, Los Angeles