Racial disparities in prostate cancer mortality: a model-based decomposition of contributing factors
Abstract
To investigate the relative contributions of natural history and clinical interventions to racial disparities in prostate cancer mortality in the United States, we extended a model that was previously calibrated to Surveillance, Epidemiology, and End Results (SEER) incidence rates for the general population and for Black men. The extended model integrated SEER data on curative treatment frequencies and cancer-specific survival. Starting with the model for all men, we replaced up to 9 components with corresponding components for Black men, projecting age-standardized mortality rates for ages 40-84 years at each step. Based on projections in 2019, the increased frequency of developing disease, more aggressive tumor features, and worse cancer-specific survival in Black men diagnosed at local-regional and distant stages explained 38%, 34%, 22%, and 8% of the modeled disparity in mortality. Our results point to intensified screening and improved care in Black men as priority areas to achieve greater equity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2023
- Source ID
- 10.1093/jncimonographs/lgad018
Entities
People
- Alexander Tsodikov
- Jane M Lange
- Jonathan E. Shoag
- Roman Gulati
- Ruth Etzioni
- Yaw Nyame
Organizations
- Case Western Reserve University
- Damon Runyon Cancer Research Foundation
- Fred Hutchinson Cancer Center
- National Cancer Institute
- Oregon Health & Science University
- United States Department of Defense
- University of Michigan
- University of Washington
- Weill Cornell Medicine