A disease severity scale for the evaluation of vaccine and other preventive or therapeutic interventions for travellers’ diarrhoea
Abstract
Travellers’ diarrhoea (TD) is the most common travel-related illness with an estimated 10 million people afflicted annually. Outcome measures to assess the efficacy of primary and secondary TD interventions were historically based on diarrhoea frequency with ≥1 associated gastrointestinal symptom. Furthermore, efficacy determination is often made on the presence or absence of TD, rather than on TD illness severity. Current severity classifications are based on subjective consideration of impact of illness on activity. We sought to develop a standardized scoring system to characterize TD severity to potentially apply as a secondary outcome in future field studies.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 06, 2021
- Source ID
- 10.1093/jtm/taab139
Entities
People
- Chad K Porter
- David R. Tribble
- Jamie A. Fraser
- Mark S. Riddle
- Nicole Maier
- Patrick Connor
- Ramiro Gutierrez
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Uniformed Services University of the Health Sciences
- United States Department of Defense