Purposeful Misalignment of Severed Nerve Stumps in a Standardized Transection Model Reveals Persistent Functional Deficit With Aberrant Neurofilament Distribution
Abstract
Functional recovery following primary nerve repair of a transected nerve is often poor even with advanced microsurgical techniques. Recently, we developed a novel sciatic nerve transection method where end-to-end apposition of the nerve endings with minimal gap was performed with fibrin glue. We demonstrated that transected nerve repair with gluing results in optimal functional recovery with improved axonal neurofilament distribution profile compared to the end-to-end micro-suture repair. However, the impact of axonal misdirection and misalignment of nerve fascicles remains largely unknown in nerve-injury recovery. We addressed this issue using a novel nerve repair model with gluing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2021
- Source ID
- 10.1093/milmed/usaa344
Entities
People
- Anagha A. Gurjar
- Andrew Rodenhouse
- John C Elfar
- Jung Il Lee
- Kristen Manto
- M. A. Hassan Talukder
- Mary O’brien
- Prem Kumar Govindappa
- Zara Karuman
Organizations
- Hanyang University
- National Institutes of Health
- Pennsylvania State University
- United States Department of Defense