Bone Morphogenetic Protein-2 Rapidly Heals Two Distinct Critical Sized Segmental Diaphyseal Bone Defects in a Porcine Model
Abstract
Segmental bone defects (SBDs) are devastating injuries sustained by warfighters and are difficult to heal. Preclinical models that accurately simulate human conditions are necessary to investigate therapies to treat SBDs. We have developed two novel porcine SBD models that take advantage of similarities in bone healing and immunologic response to injury between pigs and humans. The purpose of this study was to investigate the efficacy of Bone Morphogenetic Protein-2 (BMP-2) to heal a critical sized defect (CSD) in two novel porcine SBD models.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 24, 2021
- Source ID
- 10.1093/milmed/usab360
Entities
People
- Aamir Tucker
- Adam Gremah
- Austin E Wininger
- Emily Jewell
- Jeffrey O. Anglen
- Kaitlyn S. Griffin
- Karl D. Shively
- Melissa A. Kacena
- Michael K Savaglio
- Paul Childress
- Robyn K. Fuchs
- Roman M Natoli
- Stuart J. Warden
- Tien-min Gabriel Chu
- Todd O McKinley
Organizations
- Houston Methodist Hospital
- Indiana University
- Marian University
- National Institutes of Health
- United States Department of Defense
- University of Cincinnati