Development of a Minipig Model of BINT From Blast Exposure Using a Repeatable Mobile Shock Expansion Tube
Abstract
The Office of Naval Research (ONR) sponsored the Blast Load Assessment Sense and Test (BLAST) program to provide an approach to operationally relevant monitoring and analysis of blast exposure for optimization of service member performance and health. Of critical importance in this effort was the development of a standardized methodology for preclinical large animal studies that can reliably produce outcome measures that cannot be measured in human studies to support science-based guidelines. The primary advantage of this approach is that, because animal studies report physiological measures that correlate with human neuropathology, these data can be used to evaluate potential risks to service members by accounting for the anatomical and physiological differences between humans and large animal models. This article describes the methodology used to generate a comprehensive outcome measure dataset correlated with controlled blast exposure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 22, 2021
- Source ID
- 10.1093/milmed/usab409
Entities
People
- Elizabeth McNeil
- John W VanMeter
- Laila Zai
- Lindsey E Hulbert
- Pamela VandeVord
- Stephen Laconte
- Timothy B. Bentley
- Timothy Walilko
Organizations
- Applied Research Associates (United States)
- Georgetown University
- Kansas State University
- Office of Naval Research
- Virginia Tech