Development of a Novel Epidural Hemorrhage Model in Swine
Abstract
Traumatic brain injury is a major public health concern. Among patients with severe traumatic brain injury, epidural hemorrhage is known to swiftly lead to brain herniation and death unless there is emergent neurosurgical intervention. However, immediate neurosurgeon availability is frequently a problem outside of level I trauma centers. In this context, the authors desired to test a novel device for the emergent management of life-threatening epidural hemorrhage. A review of existing animal models determined that all were inadequate for this purpose, as they were found to be either inappropriate or obsolete. Here, we describe the development of a new epidural hemorrhage model in swine (Sus scrofa, 18-26 kg) ideal for translational device testing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 20, 2021
- Source ID
- 10.1093/milmed/usab427
Entities
People
- James D. Ross
- Oliver J Buchanan
- Ross I Donaldson
- Todd L Graham
Organizations
- Congressionally Directed Medical Research Programs
- Harbor–UCLA Medical Center
- Military & Health Research Foundation
- Oregon Health & Science University
- UCLA David Geffen School of Medicine
- University of California, Los Angeles