Development of an Animal Model of Military-Relevant Traumatic Stress
Abstract
Acute Stress Reactions (ASRs) affect a subgroup of individuals who experience traumatic stress. In the context of military operations, such reactions are often termed Combat and Operational Stress Reactions (COSRs). COSRs not only encompass all symptoms of ASRs but also include additional symptoms related to military combat and may develop at a rate higher than the general public experiences ASRs. Despite an obvious need, there are currently no approved pharmacologic treatments or guidelines for ASR and/or COSR. Preclinical rodent stress models and behavioral assessments are used to evaluate pharmacotherapies and elucidate underlying mechanisms. Here, we combined established traumatic stress models to develop a model of traumatic stress relevant to military trauma exposure and measured behavioral outcomes that reflect outcomes observed in ASRs and COSRs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 10, 2022
- Source ID
- 10.1093/milmed/usac056
Entities
People
- Boris Ngouajio
- Drew Henschen
- Emily Lowery-gionta
- Emily Scott
- Fred Johnson Iii
- Gabriella Silva
- Isaac Jeong
- Kevin Swift
- Kilana Jenkins
- Liana M. Matson
- Matthew May
- Rachel M Taylor
Organizations
- United States Army