Sustained vs. Intratidal Recruitment in the Injured Lung During Airway Pressure Release Ventilation: A Computational Modeling Perspective
Abstract
During mechanical ventilation, cyclic recruitment and derecruitment (R/D) of alveoli result in focal points of heterogeneous stress throughout the lung. In the acutely injured lung, the rates at which alveoli can be recruited or derecruited may also be altered, requiring longer times at higher pressure levels to be recruited during inspiration, but shorter times at lower pressure levels to minimize collapse during exhalation. In this study, we used a computational model to simulate the effects of airway pressure release ventilation (APRV) on acinar recruitment, with varying inspiratory pressure levels and durations of exhalation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2023
- Source ID
- 10.1093/milmed/usad059
Entities
People
- A. Fonseca Cruz
- David W. Kaczka
- Gary F Nieman
- Harry Ramcharran
- Jacob Herrmann
- Merryn Tawhai
- Michaela Kollisch-Singule
Organizations
- State University of New York Upstate Medical University
- United States Department of Defense
- University of Auckland
- University of Iowa
- University of Vermont