Ruggedized Self-Propelling Hemostatic Gauze Delivers Low Dose of Thrombin and Systemic Tranexamic Acid and Achieves High Survival in Swine With Junctional Hemorrhage
Abstract
Hemorrhage is responsible for 91% of preventable prehospital deaths in combat. Bleeding from anatomic junctions such as the groin, neck, and axillae make up 19% of these deaths, and reports estimate that effective control of junctional hemorrhage could have prevented 5% of fatalities in Afghanistan. Hemostatic dressings are effective but are time-consuming to apply and are limited when proper packing and manual pressure are not feasible, such as during care under fire. CounterFlow-Gauze is a hemostatic dressing that is effective without compression and delivers thrombin and tranexamic acid into wounds. Here, an advanced prototype of CounterFlow-Gauze, containing a range of low thrombin doses, was tested in a lethal swine model of junctional hemorrhage. Outcomes were compared with those of Combat Gauze, the current dressing recommended by Tactical Combat Casualty Care.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2023
- Source ID
- 10.1093/milmed/usad110
Entities
People
- Adele Khavari
- Andrew Beckett
- Asad Naveed
- Catherine Tenn
- Christian J Kastrup
- Christopher Sherwood
- Han Zhang Gao
- Henry Peng
- Hugh Semple
- James R Baylis
- Kristyn Ringgold
- Massimo F Cau
- Nabil Ali-mohamad
- Nathan J White
- Nuoya Peng
- Xu Wang
- Youjie Zhang
Organizations
- Congressionally Directed Medical Research Programs
- DRDC Toronto
- Defence Research and Development Canada
- Medical College of Wisconsin
- Royal Canadian Medical Service
- St. Michael's Hospital
- University of British Columbia
- University of Washington