Legal Performance-enhancing Drugs Alter Course and Treatment of Rhabdomyolysis-induced Acute Kidney Injury
Abstract
Rhabdomyolysis-induced acute kidney injury (RIAKI) can interrupt physical training and increase mortality in injured warfighters. The legal performance-enhancing drugs caffeine and ibuprofen, which can cause renal injury, are widely used by service members. Whether caffeine or ibuprofen affects RIAKI is unknown. Cilastatin treatment was recently identified as an experimental treatment to prevent RIAKI at injury. To determine potential interacting factors in RIAKI treatment, we test the hypothesis that caffeine and ibuprofen worsen RIAKI and interfere with treatment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2023
- Source ID
- 10.1093/milmed/usad142
Entities
People
- Adam C. Munhall
- Akash A Pai
- Jessica F Hebert
- Mahaba B. Eiwaz
- Megan N. Nickerson
- Michael P. Hutchens
- Nicole K. Andeen
- Tahnee Groat
Organizations
- National Center for Advancing Translational Sciences
- Oregon Health & Science University
- United States Department of Defense