Utilizing Plasma Composition Data to Help Determine Procoagulant Dynamics in Patients with Thermal Injury: A Computational Assessment
Abstract
The development of methods that generate individualized assessments of the procoagulant potential of burn patients could improve their treatment. Beyond its role as an essential intermediate in the formation of thrombin, factor (F)Xa has systemic effects as an agonist to inflammatory processes. In this study, we use a computational model to study the FXa dynamics underlying tissue factor-initiated thrombin generation in a small cohort of burn patients.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 01, 2019
- Source ID
- 10.1093/milmed/usy397
Entities
People
- Anthony E. Pusateri
- Jeffrey W. Shupp
- Kathleen E. Brummel-ziedins
- Lauren T. Moffatt
- Maria Cristina Bravo
- Marti Jett-tilton
- Melissa M. Mclawhorn
- Shawn Tejiram
- Thomas Orfeo
Organizations
- Office of Naval Research
- United States Army
- United States Army Institute of Surgical Research
- University of Vermont