Preliminary Evidence for a Hormetic Effect on DNA Nucleotide Excision Repair in Veterans with Gulf War Illness
Abstract
Veterans of the 1991 Gulf War were potentially exposed to a mixture of stress, chemicals and radiation that may have contributed to the persistent symptoms of Gulf War Illness (GWI). The genotoxic effects of some of these exposures are mediated by the DNA nucleotide excision repair (NER) pathway. We hypothesized that individuals with relatively low DNA repair capacity would suffer greater damage from cumulative genotoxic exposures, some of which would persist, causing ongoing problems.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 23, 2019
- Source ID
- 10.1093/milmed/usz177
Entities
People
- Abdullah Alhamed
- Ali Almutairy
- Jean J. Latimer
- Kimberly Sullivan
- Maria Abreu
- Nancy G. Klimas
- Stefanie Sveiven
- Stephen G Grant
Organizations
- Boston University
- Miami VA Healthcare System
- Nova Southeastern University
- South University
- United States Department of Defense