Experimental Basis for Creating an Osseointegrated Neural Interface for Prosthetic Control: A Pilot Study in Rabbits
Abstract
While debate persists over how to best prevent or treat amputation neuromas, the more pressing question of how to best marry residual nerves to state-of-the-art robotic prostheses for naturalistic control of a replacement limb has come to the fore. One potential solution involves the transposition of terminal nerve ends into the medullary canal of long bones, creating the neural interface within the bone. Nerve transposition into bone is a long-practiced, clinically relevant treatment for painful neuromas. Despite neuropathic pain relief, the physiological capacity of transposed nerves to conduct motor and sensory signals required for prosthesis control remains unknown. This pilot study addresses the hypotheses that (1) bone provides stability to transposed nerves and (2) nerves transposed into bone remain physiologically active, as they relate to the creation of an osseointegrated neural interface.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2020
- Source ID
- 10.1093/milmed/usz246
Entities
People
- Aaron J. Suminski
- Aaron M Dingle
- Augusto X T Millevolte
- Brett Nemke
- Jared P. Ness
- Joseph Novello
- Justin C Williams
- Mark D. Markel
- Ruston Sanchez
- Samuel O. Poore
- Weifeng Zeng
- Yan Lu
Organizations
- Defense Advanced Research Projects Agency
- University of Wisconsin–Madison