Towards a Treatment for Gulf War Illness: A Consensus Docking Approach
Abstract
Gulf War Illness (GWI) currently has no known cure and affects soldiers deployed during the Persian Gulf War. It is thought to originate from exposure to neurotoxicants combined with battlefield stress, and previous research indicates that treatment first involves inhibition of interleukin-2 and tumor necrosis factor alpha, followed by the glucocorticoid receptor. However, the off-target effects of pharmaceuticals hinder development of a drug treatment therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2020
- Source ID
- 10.1093/milmed/usz299
Entities
People
- Gloria E Gutierrez
- Gordon Broderick
- Jonathan Bohmann
- Nancy G. Klimas
- Rajeev Jaundoo
- Travis J A Craddock
Organizations
- Nova Southeastern University
- Rochester Institute of Technology
- Southwest Research Institute
- United States Department of Defense