Review of Biomarkers and Analytical Methods for Organophosphate Pesticides and Applicability to Nerve Agents
Abstract
Recent malicious use of chemical warfare agents (CWAs) is a reminder of their severity and ongoing threat. One of the main categories of CWAs is the organophosphate (OP) nerve agents. Presently, there is an urgent need to identify and evaluate OP nerve agent biomarkers that can facilitate identification of exposed individuals post-CWA incident. While exposures to OP nerve agents may be scenario-specific, the public is commonly exposed to OP compounds through the ubiquitous use of OP pesticides, which are chemically related to nerve agents. Therefore, a systematic literature review and methodological quality assessment were conducted for OP pesticide biomarker studies to serve as a baseline to assess if these approaches may be adapted to OP nerve agent exposures.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 20, 2020
- Source ID
- 10.1093/milmed/usz441
Entities
People
- Charles Young
- David G. Drewry Iii
- Jennifer Therkorn
- Kaitlin Rainwater-Lovett
- Mekbib Astatke
- Olivia Tiburzi
Organizations
- Defense Threat Reduction Agency