KRCC1, a modulator of the DNA damage response
Abstract
The lysine-rich coiled-coil 1 (KRCC1) protein is overexpressed in multiple malignancies, including ovarian cancer, and overexpression correlates with poor overall survival. Despite a potential role in cancer progression, the biology of KRCC1 remains elusive. Here, we characterize the biology of KRCC1 and define its role in the DNA damage response and in cell cycle progression. We demonstrate that KRCC1 associates with the checkpoint kinase 1 (CHK1) upon DNA damage and regulates the CHK1-mediated checkpoint. KRCC1 facilitates RAD51 recombinase foci formation and augments homologous recombination repair. Furthermore, KRCC1 is required for proper S-phase progression and subsequent mitotic entry. Our findings uncover a novel component of the DNA damage response and a potential link between cell cycle, associated damage response and DNA repair.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 16, 2022
- Source ID
- 10.1093/nar/gkac890
Entities
People
- Anindya Dey
- Elangovan Thavathiru
- Fiifi Neizer-ashun
- Priyabrata Mukherjee
- Resham Bhattacharya
- Shailendra Kumar Dhar Dwivedi
- Susan Patricia Lees-miller
- William L Berry
Organizations
- National Cancer Institute
- United States Department of Defense
- University of Calgary
- University of Oklahoma Health Sciences Center