A combined approach of convection-enhanced delivery of peptide nanofiber reservoir to prolong local DM1 retention for diffuse intrinsic pontine glioma treatment
Abstract
Diffuse intrinsic pontine glioma (DIPG) is a highly lethal malignancy that occurs predominantly in children. DIPG is inoperable and post-diagnosis survival is less than 1 year, as conventional chemotherapy is ineffective. The intact blood–brain barrier (BBB) blocks drugs from entering the brain. Convection-enhanced delivery (CED) is a direct infusion technique delivering drugs to the brain, but it suffers from rapid drug clearance. Our goal is to overcome the delivery barrier via CED and maintain a therapeutic concentration at the glioma site with a payload-adjustable peptide nanofiber precursor (NFP) that displays a prolonged retention property as a drug carrier.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 17, 2020
- Source ID
- 10.1093/neuonc/noaa101
Entities
People
- Adam O Michel
- Benedict Law
- Ching-Hsuan Tung
- Mark Souweidane
- Richard Ting
- Vanessa Bellat
- Yago Alcaina
Organizations
- National Cancer Institute
- NewYork–Presbyterian Hospital
- The Rockefeller University
- United States Department of Defense
- Weill Cornell Medicine