Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas
Abstract
Telomerase reverse transcriptase (TERT) is essential for tumor proliferation, including in low-grade oligodendrogliomas (LGOGs). Since TERT is silenced in normal cells, it is also a therapeutic target. Therefore, noninvasive methods of imaging TERT are needed. Here, we examined the link between TERT expression and metabolism in LGOGs, with the goal of leveraging this information for noninvasive magnetic resonance spectroscopy (MRS)-based metabolic imaging of LGOGs.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 17, 2021
- Source ID
- 10.1093/neuonc/noab093
Entities
People
- Anne Marie Gillespie
- Céline Taglang
- Georgios Batsios
- H. Artee Luchman
- Joseph F. Costello
- Pavithra Viswanath
- Peder E. Z. Larson
- Russell O. Pieper
- Sabrina M. Ronen
- Vinay Ayyappan
Organizations
- American Cancer Society
- National Institutes of Health
- United States Department of Defense
- University of Calgary
- University of California, San Francisco