Spatial concordance of DNA methylation classification in diffuse glioma
Abstract
Intratumoral heterogeneity is a hallmark of diffuse gliomas. DNA methylation profiling is an emerging approach in the clinical classification of brain tumors. The goal of this study is to investigate the effects of intratumoral heterogeneity on classification confidence.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 28, 2021
- Source ID
- 10.1093/neuonc/noab134
Entities
People
- Adriaan A Lammertsma
- Annemieke J M Rozemuller
- Floris Barthel
- Frederik Barkhof
- Jaap C Reijneveld
- Jeroen A M Beliën
- Joseph F. Costello
- Kevin C. Johnson
- Kevin J. Anderson
- Maqsood M Yaqub
- Michael D. Taylor
- Niels Verburg
- Otto S Hoekstra
- Petra J W Pouwels
- Philip C. De Witt Hamer
- Pieter Wesseling
- Roel G W Verhaak
- Ronald Boellaard
- Sunit Das
- Thomas Koopman
- William Peter Vandertop
Organizations
- American Cancer Society
- Hospital for Sick Children
- Jackson Laboratory
- KWF Kankerbestrijding
- National Cancer Institute
- Stichting Epilepsie Instellingen Nederland
- United States Department of Defense
- University College London
- University of California, San Francisco
- University of Cambridge
- University of Toronto
- VU University Medical Center
- Vrije Universiteit Amsterdam