Deuterium magnetic resonance spectroscopy enables noninvasive metabolic imaging of tumor burden and response to therapy in low-grade gliomas
Abstract
The alternative lengthening of telomeres (ALT) pathway is essential for tumor proliferation in astrocytomas. The goal of this study was to identify metabolic alterations linked to the ALT pathway that can be exploited for noninvasive magnetic resonance spectroscopy (MRS)-based imaging of astrocytomas in vivo.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 29, 2022
- Source ID
- 10.1093/neuonc/noac022
Entities
People
- Anne Marie Gillespie
- Céline Taglang
- Donghyun Hong
- Georgios Batsios
- Hema Artee Luchman
- Joydeep Mukherjee
- Meryssa Tran
- Pavithra Viswanath
- Russell O. Pieper
- Sabrina M. Ronen
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Calgary
- University of California, San Francisco