SRRM4-mediated REST to REST4 dysregulation promotes tumor growth and neural adaptation in breast cancer leading to brain metastasis
Abstract
Effective control of brain metastasis remains an urgent clinical need due a limited understanding of the mechanisms driving it. Although the gain of neuro-adaptive attributes in breast-to-brain metastases (BBMs) has been described, the mechanisms that govern this neural acclimation and the resulting brain metastasis competency are poorly understood. Herein, we define the role of neural-specific splicing factor Serine/Arginine Repetitive Matrix Protein 4 (SRRM4) in regulating microenvironmental adaptation and brain metastasis colonization in breast cancer cells.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 16, 2023
- Source ID
- 10.1093/neuonc/noad175
Entities
People
- Brooke N Nakamura
- Daniella Bamshad
- Diganta Das
- Josh Neman
- Krutika Deshpande
- Ling Shao
- Max Reed
- Mukund Iyer
- Noel J Buckley
- Vahan Martirosian
Organizations
- National Cancer Institute
- National Institutes of Health
- Susan G. Komen for the Cure
- United States Department of Defense
- University of Oxford
- University of Southern California