Metabolic reprogramming associated with aggressiveness occurs in the G-CIMP-high molecular subtypes of IDH1mut lower grade gliomas
Abstract
Early detection of increased aggressiveness of brain tumors is a major challenge in the field of neuro-oncology because of the inability of traditional imaging to uncover it. Isocitrate dehydrogenase (IDH)-mutant gliomas represent an ideal model system to study the molecular mechanisms associated with tumorigenicity because they appear indolent and non-glycolytic initially, but eventually a subset progresses toward secondary glioblastoma with a Warburg-like phenotype. The mechanisms and molecular features associated with this transformation are poorly understood.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 30, 2019
- Source ID
- 10.1093/neuonc/noz207
Entities
People
- Adrian Lita
- Aiguo Li
- Alejandra Cavazos-saldana
- Christel Herold-mende
- Chunzhang Yang
- Dionne Davis
- Houtan Noushmehr
- Hua Song
- Jane B Trepel
- Jeeva Munasinghe
- Mark R Gilbert
- Mioara Larion
- Murali Krishna Cherukuri
- Orieta Celiku
- Sue Han
- Sunmin Lee
- Tathiane M. Malta
- Thais S Sabedot
- Tomohiro Seki
- Tyrone Dowdy
- Victor Ruiz-rodado
- Wei Zhang
- Yang Liu
Organizations
- Henry Ford Health
- Henry Ford Hospital
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- National Institutes of Health
- United States Department of Defense
- University Hospital Heidelberg