A Porcine Model of Peripheral Nerve Injury Enabling Ultra-Long Regenerative Distances: Surgical Approach, Recovery Kinetics, and Clinical Relevance
Abstract
Millions of Americans experience residual deficits from traumatic peripheral nerve injury (PNI). Despite advancements in surgical technique, repair typically results in poor functional outcomes due to prolonged periods of denervation resulting from long regenerative distances coupled with slow rates of axonal regeneration. Novel surgical solutions require valid preclinical models that adequately replicate the key challenges of clinical PNI.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 11, 2020
- Source ID
- 10.1093/neuros/nyaa106
Entities
People
- D Kacy Cullen
- Daniel P. Brown
- Dmitriy Petrov
- Douglas H. Smith
- Franco A. Laimo
- H. Isaac Chen
- Harry C. Ledebur
- Hilton M. Kaplan
- John A Wolf
- John L Dutton
- Joseph M. Rosen
- Justin C. Burrell
- Kevin D. Browne
- Sanford Roberts
- Suradip Das
- Zarina Ali
Organizations
- Dartmouth College
- Rutgers University
- University of Pennsylvania