Dynamics of Human Immunodeficiency Virus-1 Genetic Diversification During Acute Infection
Abstract
We analyzed human immunodeficiency virus envelope diversity in 98 acute infections. The within-host genetic diversity, divergence from transmitted/founder (T/F) strain, and the observed frequency of multiple T/F infections increased with Fiebig stage. These data identify rapid viral dynamics during acute infection with implications for clinical trials conducted in this setting.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 12, 2020
- Source ID
- 10.1093/ofid/ofaa429
Entities
People
- Anne Marie O’sullivan
- Bessara Nuntapinit
- Daniel Silas
- Eric Sanders-buell
- Eugène Kroon
- Hongshuo Song
- Jintanat Ananworanich
- Mark de Souza
- Meera Bose
- Merlin L Robb
- Nelson Michael
- Phuc T Pham
- Rapee Trichavaroj
- Robert A Gramzinski
- Sandhya Vasan
- Siriwat Akapirat
- Sodsai Tovanabutra
- Suteeraporn Pinyakorn
Organizations
- Armed Forces Research Institute of Medical Sciences
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- National Institute of Allergy and Infectious Diseases
- United States Army Medical Research and Development Command
- United States Department of Defense
- University of Amsterdam
- University of Maryland, Baltimore
- Walter Reed Army Institute of Research