450. Type I Interferon Autoantibodies Are Detected in Those with Critical COVID-19, Including a Young Female Patient
Abstract
Approximately 10-20% of patients with critical COVID-19 harbor neutralizing autoantibodies (auto-Abs) that target type I interferons (IFN), a family of cytokines that induce critical innate immune defense mechanisms upon viral infection. Studies to date indicate that these auto-Abs are mostly detected in men over age 65.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2021
- Source ID
- 10.1093/ofid/ofab466.649
Entities
People
- Allison Malloy
- Andrew L. Snow
- Brian K. Agan
- David A. Lindholm
- David R. Tribble
- Debra Yee
- Elana Shaw
- Emily Samuels
- Eric Laing
- Helen Su
- Jean-Laurent Casanova
- Katrin Mende
- Lindsey B Rosen
- Marana Tso
- Mark P Simons
- Paul Bastard
- Simon Pollett
- Stephanie A Richard
- Steven M. Holland
- Tahaniyat Lalani
- Timothy Burgess
Organizations
- National Institute of Allergy and Infectious Diseases
- The Rockefeller University
- Uniformed Services University of the Health Sciences
- Walter Reed National Military Medical Center