461. Classical Antigen Presenting Cell Activation Correlates with T Cell Immunity and COVID-19 Severity
Abstract
The initial response of immune cells against respiratory viruses often determines the severity and duration of disease. The early trajectory of the immune response during infection with SARS-CoV-2 remains poorly understood. Dysregulation of innate immune factors that facilitate viral clearance and the adaptive response, such as type I interferons, have been implicated in severe COVID-19. However, collection of biological samples during the first seven days post-symptom onset has posed a logistical challenge, limiting our knowledge surrounding the immune responses that drive protection versus immunopathology.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 01, 2021
- Source ID
- 10.1093/ofid/ofab466.660
Entities
People
- Allison M Malloy
- Andrew L. Snow
- Brian K. Agan
- Camille Lake
- Clifton L Dalgard
- Jarina Pena-damata
- Josh Chenoweth
- Katherine Pohida
- Mark P Simons
- Nusrat J Epsi
- Paul W. Blair
- Simon Pollett
- Stephanie A Richard
- Timothy Burgess
- Zhongyan Lu
Organizations
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences