Evaluating Demographic Representation in Clinical Trials: Use of the Adaptive Coronavirus Disease 2019 Treatment Trial (ACTT) as a Test Case
Abstract
Clinical trials initiated during emerging infectious disease outbreaks must quickly enroll participants to identify treatments to reduce morbidity and mortality. This may be at odds with enrolling a representative study population, especially when the population affected is undefined.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 27, 2023
- Source ID
- 10.1093/ofid/ofad290
Entities
People
- Adam J Langer
- Ana M Ortega-Villa
- Andre C Kalil
- Aneesh K. Mehta
- Angela R. Branche
- Annie Luetkemeyer
- Barry S Zingman
- Cameron R. Wolfe
- Carlos A. Gómez
- Catharine I Paules
- Christopher J. Colombo
- Constance A Benson
- Corri B Levine
- Daniel A. Sweeney
- Dilek Ince
- Hana M El Sahly
- Hannah Jang Kim
- Jennifer A Whitaker
- Jing Wang
- Jocelyn Voell
- Jonathan M Wortham
- Katherine Yang
- Kay M. Tomashek
- Lori E Dodd
- Mamta K. Jain
- Michael Whitaker
- Michelle S Harkins
- Nicole M. Iovine
- Nikolaus Jilg
- Noreen A Hynes
- Richard A Mularski
- Richard T. Davey Jr.
- Robert Grossberg
- Robert L Atmar
- Sarah L George
- Seema U Nayak
- Stuart H Cohen
- Tatiana Beresnev
- Varduhi Ghazaryan
- Victor Tapson
- William R Short
- Zanthia Wiley
Organizations
- Albert Einstein College of Medicine
- Baylor College of Medicine
- Cedars-Sinai Medical Center
- Duke University
- Emory University
- Frederick National Laboratory for Cancer Research
- Harvard Medical School
- Johns Hopkins University
- Kaiser Permanente
- Madigan Army Medical Center
- Massachusetts General Hospital
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Saint Louis University
- Uniformed Services University of the Health Sciences
- University of California, Davis
- University of California, San Diego
- University of California, San Francisco
- University of Florida Health
- University of Iowa
- University of Nebraska Medical Center
- University of Pennsylvania
- University of Texas Medical Branch
- University of Texas at Austin