A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses
Abstract
Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2016
- Source ID
- 10.1093/ofid/ofw007
Entities
People
- Aimee K. Zaas
- Alfred O. Hero III
- Anthony Gilbert
- Bradly P. Nicholson
- Christopher W Woods
- Ephraim L Tsalik
- Geoffrey S Ginsburg
- Lawrence P. Park
- Lori L. Hudson
- Marshall Nichols
- Micah T McClain
- Robert Lambkin-Williams
- Thomas Burke
- Timothy Veldman
- Tzu-yu Liu
Organizations
- Defense Advanced Research Projects Agency
- Duke University
- National Center for Genome Resources
- University of Michigan