IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts
Abstract
Interleukin 11 (IL11) is highly upregulated in skin and lung fibroblasts from patients with systemic sclerosis (SSc). Here we tested whether IL11 is mechanistically linked with activation of human dermal fibroblasts (HDFs) from patients with SSc or controls.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 16, 2021
- Source ID
- 10.1093/rheumatology/keab168
Entities
People
- Andrea Low Hsiu Ling
- Anissa A Widjaja
- Benjamin L George
- Benjamin Ng
- Bhairav S Paleja
- Bruno Reversade
- Eleonora Adami
- Jessie Tan
- Kakaly Ghosh
- Nevin Zhihao
- Pei Min Lio
- Salvatore Albani
- Sebastian Schäfer
- Sivakumar Viswanathan
- Sonia Chothani
- Steven O'Reilly
- Stuart Cook
- Umut Altunoglu
Organizations
- Agency for Science, Technology and Research
- Durham University
- Koç University
- National Heart Centre Singapore
- National Medical Research Council
- National University of Singapore
- Naval Medical Research Center
- Singapore General Hospital