Sleep and diurnal rest-activity rhythm disturbances in a mouse model of Alzheimer’s disease
Abstract
Accumulating evidence suggests a strong association between sleep, amyloid-beta (Aβ) deposition, and Alzheimer’s disease (AD). We sought to determine if (1) deficits in rest-activity rhythms and sleep are significant phenotypes in J20 AD mice, (2) metabotropic glutamate receptor 5 inhibitors (mGluR5) could rescue deficits in rest-activity rhythms and sleep, and (3) Aβ levels are responsive to treatment with mGluR5 inhibitors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 05, 2020
- Source ID
- 10.1093/sleep/zsaa087
Entities
People
- Cara J Westmark
- Carissa L Verkuilen
- Dylan J Douglas
- Eli Wallace
- Lauren I Steinberg
- Mikolaj J. Filon
- Pamela R Westmark
- Rama Maganti
- Samantha Wright
Organizations
- Fraxa Research Foundation
- National Center for Advancing Translational Sciences
- National Institute on Aging
- National Institutes of Health
- United States Department of Defense
- University of Wisconsin–Madison