Immunization with a heat-killed bacterium, Mycobacterium vaccae NCTC 11659, prevents the development of cortical hyperarousal and a PTSD-like sleep phenotype after sleep disruption and acute stress in mice
Abstract
Sleep deprivation induces systemic inflammation that may contribute to stress vulnerability and other pathologies. We tested the hypothesis that immunization with heat-killed Mycobacterium vaccae NCTC 11659 (MV), an environmental bacterium with immunoregulatory and anti-inflammatory properties, prevents the negative impacts of 5 days of sleep disruption on stress-induced changes in sleep, behavior, and physiology in mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 07, 2020
- Source ID
- 10.1093/sleep/zsaa271
Entities
People
- Christopher Lowry
- Fred W. Turek
- Kenneth P. Wright Jr.
- Martha H Vitaterna
- Monika Fleshner
- Samuel J Bowers
- Shannon He
- Sophie Lambert
Organizations
- National Institutes of Health
- Northwestern University
- Office of Naval Research
- University of Colorado Boulder