HIV increases sleep-based brain age despite antiretroviral therapy
Abstract
Age-related comorbidities and immune activation raise concern for advanced brain aging in people living with HIV (PLWH). The brain age index (BAI) is a machine learning model that quantifies deviations in brain activity during sleep relative to healthy individuals of the same age. High BAI was previously found to be associated with neurological, psychiatric, cardiometabolic diseases, and reduced life expectancy among people without HIV. Here, we estimated the effect of HIV infection on BAI by comparing PLWH and HIV− controls.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 30, 2021
- Source ID
- 10.1093/sleep/zsab058
Entities
People
- Christine L Boutros
- Elissa Ye
- Gregory K. Robbins
- Haoqi Sun
- Lee Sullivan
- Lin Liu
- M. Brandon Westover
- Michael J. Leone
- Robert J. Thomas
- Shibani S. Mukerji
Organizations
- American Academy of Sleep Medicine
- American Federation for Aging Research
- Beth Israel Deaconess Medical Center
- Glenn Foundation for Medical Research
- Harvard University
- Harvard University Center for AIDS Research
- Massachusetts General Hospital
- National Institutes of Health
- United States Department of Defense