Dual orexin antagonist normalized sleep homeostatic drive, enhanced GABAergic inhibition, and suppressed seizures after traumatic brain injury

Abstract

Traumatic brain injury (TBI) can result in posttraumatic epilepsy (PTE) and sleep disturbances. We hypothesized that treatment with sleep aids after TBI can ameliorate PTE.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: Sep 27, 2022
• Source ID: 10.1093/sleep/zsac238

Entities

People

• Danny J. Lasky
• Jesse R Isaacson
• Mathew V Jones
• Rama Maganti
• Rohan K Rao
• Sophie J Rewey
• Sruthi R Konduru
• Swati S Vattem
• Zihao Zhou

Organizations

• National Institutes of Health
• Rock Bridge High School
• United States Department of Defense
• University of Wisconsin–Madison
• Wayne State University

Tags

Fields of Study

• Medicine
• Psychology

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