Brain Perfusion Mediates the Relationship Between miRNA Levels and Postural Control
Abstract
Transcriptomics, regional cerebral blood flow (rCBF), and a virtual reality-based spatial motor task were integrated using mediation analysis in a novel demonstration of “imaging omics.” Data collected in National Collegiate Athletic Association (NCAA) Division I football athletes cleared for play before in-season training showed significant relationships in 1) elevated levels of miR-30d and miR-92a to elevated putamen rCBF, 2) elevated putamen rCBF to compromised Balance scores, and 3) compromised Balance scores to elevated microRNA (miRNA) levels. rCBF acted as a consistent mediator variable (Sobel’s test P < 0.05) between abnormal miRNA levels and compromised Balance scores. Given the involvement of these miRNAs in inflammation and immune function and that vascular perfusion is a component of the inflammatory response, these findings support a chronic inflammatory model in these athletes with 11 years of average football exposure. rCBF, a systems biology measure, was necessary for miRNA to affect behavior.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 01, 2020
- Source ID
- 10.1093/texcom/tgaa078
Entities
People
- Alexa E Walter
- Amy A Herrold
- Anne J Blood
- Barbara Knollmann-Ritschel
- Eric A. Nauman
- For The Concussion Neuroimaging Consortium
- Hans C. Breiter
- James L Reilly
- Jaroslaw Harezlak
- Khrystyna Stetsiv
- Linda Papa
- Manish Bhomia
- Nicole L. Vike
- Peter H Seidenberg
- Semyon Slobounov
- Sumra Bari
- Thomas M. Talavage
- Yufen Chen
- Zoran Martinovich
Organizations
- Harvard Medical School
- Indiana University
- Istituto Superiore di Sanità
- National Science Foundation
- Northwestern University
- Orlando Regional Medical Center
- Pennsylvania State University
- Purdue University
- Uniformed Services University of the Health Sciences
- United States Department of Defense
- Veterans Health Administration