Blocking protein myristoylation inhibits prostate cancer progression
Abstract
Protein N‐myristoylation enables localization to membranes and helps maintain protein conformation and function. N‐myristoyltransferases (NMT) catalyze co‐ or post‐translational myristoylation of Src family kinases and other oncogenic proteins, thereby regulating their function. The goal of this study is 1) to demonstrate that N‐myristoylation is essential for the tumorigenic potential of oncogenioc proteins such as Src kinase; 2) to identify novel lead compounds to inhibit the NMT enzymatic functions; 3) to demonstrate that the compound exhibits its inhibitory function on cancer progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.531.2
Entities
People
- Houjian Cai
- Omar Awad Alsaidan
- Sung Jin Kim
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Georgia