Identification of key regions mediating human melatonin type 1 receptor biased signaling revealed by natural variants
Abstract
Melatonin is a circulating neurohormone mainly released from the pineal gland in a circadian manner regulating many physiological functions, such as glycemia homeostasis. A misregulation of the glycemia could lead to Type 2 Diabetes (T2D). Recently, a genetic variant (rs2119882) found on melatonin type 1 receptor (MT1) promoter has been associated to higher risks to develop T2D.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.555.10
Entities
People
- Alan Hegron
- Amélie Bonnefond
- Bianca Plouffe
- Christian Le Gouill
- Michel Bouvier
- Philippe Froguel
- Ralf Jockers
- Wenwen Gao
Organizations
- Agence Nationale de la Recherche
- Canadian Institutes of Health Research
- Defense Advanced Research Projects Agency
- Fondation pour la Recherche Médicale
- Hôpital Cochin
- Institut Pasteur de Lille
- National Institutes of Health
- National Science Foundation
- Paris 8 University
- Université de Montréal