Ibuprofen increases resistance to exertional heat stroke in female mice
Abstract
The impact of nonsteroidal anti‐inflammatory drugs (NSAIDs) on the severity or susceptibility to exertional heat stroke (EHS) is unknown. Previous studies have demonstrated that in humans, thermogenic responses to endurance exercise are suppressed by NSAIDs and that NSAIDs increase the endurance time to exhaustion in rats. However, NSAIDs have also been shown to contribute to organ damage in both severe exercise alone and in conditions of heat stress alone, which may limit performance.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.590.13
Entities
People
- Alex Mattingly
- Christian Kyle Garcia
- Gerard Robinson
- Jamal Alzahrani
- Kevin O Murray
- Orlando Laitano
- Thomas L Clanton
Organizations
- United States Department of Defense
- University of Florida