Epigenetic responses to exertional heat stroke in mice: a potential link to long term Ca2+ dysregulation in skeletal muscle
Abstract
Exposure to extreme environments can induce a long‐term epigenetic memory of stress that is stored as altered DNA‐methylation and/or histone posttranslational modifications. These ultimately affect gene and protein expression as well as cellular functions. Exertional heat stroke (EHS) is a life‐threatening stress, but whether it induces epigenetic changes is unknown. Previous studies have suggested long‐term complications of EHS that could be mediated by epigenetics, including greater vulnerability to disease, heat stress susceptibility and disordered muscle Ca2+ signaling; the latter characterized as a malignant‐hyperthermia‐type muscle phenotype, based on the in vitro contracture test (IVCT).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.590.14
Entities
People
- Christian Garcia
- Gerard Robinson
- Jamal Alzahrani
- John Iwaniec
- Kevin O Murray
- Laila Sheikh
- Orlando Laitano
- Rasha Hammamieh
- Ross Campbell
- Ruoting Yang
- Thomas L Clanton
Organizations
- United States Department of Defense
- University of Florida