Long‐term Delivery of “Low Dose” Repetitive Intermittent Hypoxia is Not Associated with Detectable Pathology
Abstract
Repetitive acute intermittent hypoxia (rAIH) is a promising therapeutic strategy to induce spinal plasticity and improve respiratory and non‐respiratory function after chronic, incomplete spinal cord injury. Although brief rAIH exposures ( 0.50), nor did we observe any evidence of pathology in the heart, aorta, liver or kidney. We found no evidence of hippocampal cell death and/or reactive gliosis based on cressyl violet, NeuN, cd11b and GFAP staining. Bone density analyses are pending, but preliminary results indicate significant bone loss only as a result of C2Hx, but not rAIH. These results add to a building body of evidence that prolonged, “low dose” rAIH is a safe, simple and effective means to improve respiratory and non‐respiratory motor function after chronic spinal cord injury.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.625.11
Entities
People
- Alec K. Simon
- Amy E. Poirier
- Arash Tadjalli
- Ashley E. Holland
- Ashley J. Ross
- Elisa Janine Gonzalez‐rothi
- Gordon S. Mitchell
- Irawan Satriotomo
- Joshua F. Yarrow
- Juan Santiago‐moreno
- Juliet V. Santiago
- Kelsey A. Stefan
- Kristin N. Smith
- Latoya A. Allen
- Marissa C. Ciesla
- Mia N. Kelly
- Raphael Perim
- Yasin B. Seven
- Zachary A. Asa
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Florida