Deciphering DYRK1A Signaling using Proteomics and Transcriptomics

Abstract

Trisomy 21 is the most common genetic manifestation of intellectual disability, with deleterious brain phenotypes thought to be caused by increased dosage of critical genes on chromosome 21, including the kinase DYRK1A. Additionally, individuals with Down syndrome are at an increased risk of developing Alzheimer's disease, immune dysfunction and certain cancers, and DYRK1A has been implicated in each of these conditions.

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 01, 2018
Source ID
10.1096/fasebj.2018.32.1_supplement.662.22

Entities

People

  • Christopher C Ebmeier
  • Helen Simpson
  • Maria Pagratis
  • Tristan Mcclure‐begley
  • William M. Old
  • Zachary Poss

Organizations

  • Defense Advanced Research Projects Agency
  • University of Colorado Boulder

Tags

Fields of Study

  • Biology

Readers

  • Molecular and genetic basis of cancer.
  • Research Science/Academic Research
  • Traumatic Brain Injury (TBI) and Cognitive Aging in the Guam and Border Populations Affected by Alzheimer's Disease and Tau-Associated Dementias.

Technology Areas

  • Biotechnology