Peripheral Adipose Arteriole Dilator Response to Amyloid Proteins and Palmitic Acid Recapitulates Central Leptomeningeal Arteriole Response: Validation of a Novel Human Tissue Model
Abstract
Cerebrovascular dysfunction is critical in the pathophysiology of Alzheimer's disease and related dementia disorders (ADRD). The relationship between cardiovascular risk factors (e.g. saturated fatty acid palmitic acid PA) and amyloid proteins (Aβ or medin) in ADRD is unknown. Treatments that worked on animal models have failed to work in humans, pointing to the need to develop human tissue‐based models that recapitulate human condition. We showed feasibility of using cadaver leptomeningeal arterioles (LMA) following rapid autopsy to study central arteriole physiology but availability is extremely limited to few centers. Abdominal adipose arterioles (AA), on the other hand, are relatively easy/safe to obtain but require validation to confirm whether physiologic responses parallel cerebrovascular responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.712.6
Entities
People
- Geidy Serrano
- Hannah Davies
- Jillian Madine
- Nina Karamanova
- Raymond Q. Migrino
- Seth Truran
- Thomas Beach
Organizations
- Arizona Biomedical Research Commission
- Arizona Department of Health Services
- Banner Sun Health Research Institute
- British Heart Foundation
- National Institutes of Health
- United States Department of Defense
- University of Arizona
- University of Liverpool