The Effects of Hypoxia and Inflammation on Claudin‐1 in CaCo‐2 Cells as a Model Intestinal Epithelium.
Abstract
The use of hydrocortisone in association with indomethacin is a known risk factor for spontaneous intestinal perforation in extremely low birthweight infants. Hypoxia, inflammation and non‐steroidal anti‐inflammatory drugs independently alter apical junctional complexes of epithelial cells. We are interested in understanding the combined effects of hypoxia, inflammation and non‐steroidal anti‐inflammatory drugs on the apical junctional complex and barrier integrity in a gastrointestinal epithelial cell model.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.748.3
Entities
People
- Chelsea E. Cole
- Gabrielle E. Largoza
- Jonathan M. King
- Nicholas B. Alana
- Nicholas R. Carr
Organizations
- Leeds Trinity University
- San Antonio Military Medical Center
- Trinity University
- United States Air Force