Biosynthesis of acyl‐CoAs sustains prostate cancer progression
Abstract
Fatty acid metabolism is essential for the biogenesis of cellular components and ATP production to sustain proliferation of cancer cells. Bioconversion of exogenous or de novo synthesized fatty acids to their corresponding fatty acyl‐CoAs, which is required for the fatty acids to participate in metabolic processes, is catalyzed by long chain fatty acyl‐CoA synthetases (ACSLs). However, the influence of individual ACSL isoforms on the progression of prostate cancer remains unknown. The goal of this study is 1) to analyze how ACSLs regulates the biosynthesis of acyl‐CoAs, thereby prostate cancer progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.811.1
Entities
People
- Houjian Cai
- Yongjie Ma
Organizations
- National Institutes of Health
- United States Department of Defense
- University of Georgia