Resuscitation with Fresh Whole Blood Improves Long Term Restoration of Muscle Strength following Hemorrhage and Limb Ischemia‐Reperfusion Injury
Abstract
Extremity vascular injuries are commonplace in battlefield trauma and often result in ischemia‐reperfusion injury (I‐R). Fluid resuscitation following hemorrhage is often required. We compared the impact of resuscitation with colloid, Hextend™ (HEX), and fresh whole blood (FWB) on markers of microvascular damage and long‐term muscle function. Using a rodent model of combined hemorrhage and tourniquet induced I‐R injury, we tested the hypotheses that, compared to resuscitation with HEX, FWB 1) mitigates microvascular damage; and, 2) results in greater return of long‐term muscle strength.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.816.4
Entities
People
- Amit Aurora
- Janet L. Roe
- Thomas J. Walters
Organizations
- United States Army Medical Research and Development Command