Effects of Resuscitation Adjuncts on Indices of Inflammation and Oxidant Stress in Tissues from Swine Subjected to Traumatic Hemorrhage
Abstract
In the absence of blood products, pre‐hospitaluse of small volume adjuncts to enhance crystalloid resuscitation has beenproposed to reduce inflammation and improve outcomes in the bleeding traumapatient. However, the most effective drugs for this purpose remain underintense investigation. The present study investigated the effects of Poloxamer‐188(P‐188), a surfactant with membrane resealing activity andethynylestradiol‐3‐sulfate (EE‐3‐S), an estrogen compound, on indices ofinflammation and oxidant stress in tissues from swine subjected to traumatichemorrhage. Both compounds are suggested to have anti‐inflammatory andpotentially anti‐oxidant activity.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.817.3
Entities
People
- Johnny L. Barr
- Michael A. Dubick
- Theo W. Thomas
- Wenjun Z. Martini
Organizations
- United States Army Institute of Surgical Research