Vasopressin's Role in Stress Response and Glucose Homeostasis in a Pig Model of Endotoxin‐Induced Inflammation
Abstract
Both acute stress hyperglycemia and uncontrolled hypoglycemia may serve as indices of disease severity in critically ill patients, yet the mechanisms behind altered glucose control in inflammatory diseases such as acute sepsis is poorly understood. Evidence of the ability of vasopressin to mediate central and peripheral glucose regulation via V1b and V1a receptors has mounted over the years, but the role of vasopressin in glucose homeostasis during sepsis, is unclear. We hypothesized that vasopressin is involved in glycemic control in endotoxin‐induced inflammation seen in sepsis but that this role may be overshadowed by vasopressin's primary role of maintaining blood pressure in the face of septic shock. Thus, we used a piglet model of endotoxin‐induced pulmonary hypertension in the absence of systemic shock to better understand the relationship between vasopressin and glucose homeostasis in a hypoxemia‐induced inflammatory state. The intent was to study effects of vasopressin separate from its role in blood pressure regulation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2018
- Source ID
- 10.1096/fasebj.2018.32.1_supplement.905.1
Entities
People
- Catherine F. T. Uyehara
- Claudia A. Hernandez
- Dao H. Ho
- Jauchia W. Blythe
- Jillian M. Piaggione
- Lee‐ann M. Murata
- Wayne M. Ichimura
- William J. Sherman
Organizations
- Tripler Army Medical Center
- United States Army Medical Command