Effects of Ketamine on Cardiovascular and Respiratory Responses to a Moderate 40 Percent Hemorrhage in Rats

Abstract

Currently, ketamine is recommended for analgesic use on the battlefield for Soldiers with severe hemorrhage. However, there have been few human or animal studies to support such use. Because of the dearth of controlled experimental evidence for use of ketamine as an analgesic during hypovolemia, the following study was conducted to determine effects of an intravascular analgesic dose of ketamine on cardiovascular and respiratory responses to a 40% hemorrhage in conscious rats.

Document Details

Document Type
Pub Defense Publication
Publication Date
Apr 01, 2018
Source ID
10.1096/fasebj.2018.32.1_supplement.910.10

Entities

People

  • Alfredo S. Calderon
  • Carmen Hinojosa‐laborde
  • Harold G. Klemcke
  • Mariam L. Calderon
  • Stephen L. Crimmins

Organizations

  • United States Army Institute of Surgical Research
  • United States Army Medical Research and Development Command

Tags

Fields of Study

  • Biology
  • Medicine

Readers

  • Cardiovascular Physiology
  • Toxicology/Environmental Toxicology